Article
CYP2C9 and VKORC1 genotyping for the quality of long-standing warfarin treatment in Russian patients.
The pharmacogenomics journal - 1 Oct 2020
Panchenko Elizaveta, Kropacheva Ekaterina, Dobrovolsky Anatoly, Titaeva Elena, Zemlyanskaya Oksana, Trofimov Dmitry, Galkina Irina, Lifshits Galina, Vereina Natalya, Sinitsin Sergey, Vorobyeva Nadezda, Grehova Lyudmila, Zateyshchikov Dmitry, Zotova Irina, Vavilova Tatyana, Sirotkina Olga, Grontkovskaya Alevtina
Abstract excerpt
A total of 263 warfarin naive patients with indications to long-term anticoagulation were included in prospective multicenter study and randomized into Pharmacogenetics and Standard dosing groups. The loading warfarin dose in Pharmacogenetics group was calculated by Gage algorithm and corrected starting on day 5 of treatment according to INR. In Standard dosing group warfarin initial dose was 5 mg and starting on...
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