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Article

Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA.

Cell reports - 4 Feb 2020

Agarwal Stuti, Kraus Zachary, Dement-Brown Jessica, Alabi Oyeleye, Starost Kyle, Tolnay Mate

Abstract excerpt

Human Fc receptor-like 3 (FCRL3) is an orphan receptor expressed by lymphocytes, including regulatory T cells. FCRL3 is implicated in several autoimmune diseases; however, its function on regulatory T cells is unknown. We discovered that FCRL3 stimulation of regulatory T cells inhibited their suppressive function. Moreover, FCRL3 stimulation induced IL-17, IL-26, and IFNγ production and promoted expression of the...

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Identifiers

PMID: 32023449
DOI: 10.1016/j.celrep.2019.12.099

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