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Article

A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.

Arthritis and rheumatism - 1 Aug 2012

Bajpai Urmila D, Swainson Louise A, Mold Jeff E, Graf Jonathan D, Imboden John B, McCune Joseph M

Abstract excerpt

OBJECTIVE: CD4+FoxP3+ Treg cells suppress effector T cells and prevent autoimmune disease. Treg cell function is deficient in active rheumatoid arthritis (RA), a loss which may play a role in the pathogenesis of this disease. We previously showed that a single-nucleotide polymorphism in the FCRL3 gene led to higher expression of Fc receptor-like 3 (FcRL3) on Treg cells and that FcRL3+ Treg cells are functionally...

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Identifiers

PMID: 22392608
DOI: 10.1002/art.34457
PMCID: PMC3374037

Genes

FCRL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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