Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.

doi:10.1371/journal.pntd.0008029

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Article

Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.

PLoS neglected tropical diseases - 1 Feb 2020

Dos Santos Jéssica Cristina, Leite Quixabeira Valéria Bernadete, Teodoro Silva Muriel Vilela, Damen Michelle S M A, Schraa Kiki, Jaeger Martin, Oosting Marije, Keating Samuel T, Dorta Miriam Leandro, Alves Pinto Sebastião, Bugalho Duarte Fernanda, de Araújo Pereira Ledice Inácia, Netea Mihai G, Ribeiro-Dias Fátima, Joosten Leo A B

Abstract excerpt

Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent on the time exposed to L. amazonensis and L. braziliensis antigens. Moreover, for the first time we show the...

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PMID: 32023240
DOI: 10.1371/journal.pntd.0008029
PMCID: PMC7028298

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