Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

doi:10.3389/fcimb.2024.1487255

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Oliveira Iara Barreto Neves, Nunes Ramon Vieira, Leite Vanessa Rafaela Milhomem Cruz, Araújo Camila Freire, Silveira Murilo Barros, Pinto Sebastião Alves, Lamounier Lorena Andrade, Borges Clayton Luiz, Martins Edésio, Porto Iane de Oliveira Pires, Gomes Rodrigo Saar, Ribeiro-Dias Fátima

Abstract excerpt

Background: The vitamin D pathway contributes to the microbicidal activity of macrophages against Leishmania infection. In addition to induction of this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part of a network of pro-inflammatory cytokines. The aim of this study was to evaluate single-nucleotide polymorphisms (SNPs) in the components of the vitamin D pathway and associated cytokine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Leishmaniasis, Cutaneous

Share to Polymorphism, Single Nucleotide

Share to Receptors, Calcitriol

Share to Treatment Outcome

Share to Vitamin D

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 39844838
DOI: 10.3389/fcimb.2024.1487255
PMCID: PMC11750871

Genes

VDR
CYP27B1
IL15
IL32
IL6
IFNG
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.PMID 39844838Read ↗

Genetic variations in the human immune system influence susceptibility to tegumentary leishmaniasis: a systematic review and meta-analysis.Semantic proximity Read ↗

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes.Semantic proximity Read ↗

Meta-Analysis of Human Toll-Like Receptor-1 Polymorphisms rs4833095 and rs5743618 and Leprosy DevelopmentSemantic proximity Read ↗

The association of serum level and polymorphisms of IFN-γ (rs2069705) with the susceptibility to cutaneous leishmaniasis.Semantic proximity Read ↗

Single nucleotide polymorphisms in genes involved in immune responses and outcome of tegumentary leishmaniasis.Semantic proximity Read ↗

The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.Semantic proximity Read ↗

A fine mapping of single nucleotide variants and haplotype analysis of IL13 gene in patients with Leishmania guyanensis-cutaneous leishmaniasis and plasma cytokines IL-4, IL-5, and IL-13.Semantic proximity Read ↗

Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.Semantic proximity Read ↗

<i>IL6</i>−174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in BrazilSemantic proximity Read ↗

Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.Semantic proximity Read ↗

A genome-wide association study highlights a regulatory role for <i>IFNG-AS1</i> contributing to cutaneous leishmaniasis in BrazilSemantic proximity Read ↗

The molecular and histopathological investigations of TLR2 rs5743708 and TLR4 (rs4986790 and rs4986791) polymorphisms effects on cutaneous leishmaniasis lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.