Article

Limiting intestinal iron absorption rescues glial defects and extends lifespan in a Drosophila model of Friedreich’s ataxia

2026-06-08

Abstract excerpt

Friedreich ataxia (FRDA) is a neurodegenerative and cardiac disease caused by GAA repeat expansions within the first intron of the FXN gene, leading to reduced frataxin expression. Frataxin is required for iron sulfur cluster (ISC) biosynthesis, and its deficiency results in multiple cellular dysfunctions, including mitochondrial iron overload. Although altered iron homeostasis has been reported in several fratax...

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Literature Corpus work: 60560ec8-87bc-5c40-9c18-718252f46a6e
DOI: 10.64898/2026.06.04.730074

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