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Article

Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1.

Scientific reports - 3 Feb 2020

Fernandes-Freitas Isabel, Milona Alexandra, Murphy Kevin G, Dhillo Waljit S, Owen Bryn M

Abstract excerpt

The nuclear hormone receptor Dax1 functions during development as a testes-determining gene. However, the phenotype of male mice lacking Dax1 is strain-dependent due to the background-specific abundance of male-determining Sry gene-transcripts. We hypothesised that inter-individual variation in Sry mRNA-abundance would result in a spectrum of phenotypes even within-strain. We found that while all XY C57BL/6J mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32015477
DOI: 10.1038/s41598-020-58788-9
PMCID: PMC6997165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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