Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex determination: a 'window' of DAX1 activity.

Trends in endocrinology and metabolism: TEM - 1 Apr 2004

Ludbrook Louisa M, Harley Vincent R

Abstract excerpt

Traditionally, DAX1 was considered an 'anti-testis' gene because DAX1 duplications in XY individuals cause male-to-female sex reversal: dosage-sensitive sex reversal (DSS). In DSS, two active DAX1 genes on one X chromosome can abrogate testis formation. By contrast, mutations and deletions of DAX1 cause adrenal hypoplasia congenita (AHC). Although AHC patients develop testes, gonadal defects include disorganized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DAX-1 Orphan Nuclear Receptor
Share to DNA-Binding Proteins
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Retinoic Acid

Share to Repressor Proteins

Share to Sex Determination Processes

Share to Sexual Maturation

Share to Testis

Source

Identifiers

PMID: 15046740
DOI: 10.1016/j.tem.2004.02.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex determination: a 'window' of DAX1 activity.PMID 15046740Read ↗

Hypogonadotropic hypogonadism in subjects with DAX1 mutations.Semantic proximity Read ↗

DAX-1, an "antitestis" gene.Semantic proximity Read ↗

DAX1 and its network partners: exploring complexity in development.Semantic proximity Read ↗

DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual DifferentiationSemantic proximity Read ↗

The role of SF1/DAX1 in adrenal and reproductive function.Semantic proximity Read ↗

Congenital adrenal hypoplasia and DAX-1 gene mutations.Semantic proximity Read ↗

A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism.Semantic proximity Read ↗

Expression of DAX-1, the Gene Responsible for X-Linked Adrenal Hypoplasia Congenita and Hypogonadotropic Hypogonadism, in the Hypothalamic-Pituitary-Adrenal/Gonadal AxisSemantic proximity Read ↗

A phenotypic spectrum of sexual development in Dax1 (Nr0b1)-deficient mice: consequence of the C57BL/6J strain on sex determination.Semantic proximity Read ↗

Leydig Cell–Specific DAX1-Deleted Mice Has Higher Testosterone Level in the Testis During Pubertal DevelopmentSemantic proximity Read ↗

DAX1 and X-linked adrenal hypoplasia congenita: clinical and molecular analysis in five patientsSemantic proximity Read ↗

Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.