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Article

Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse.

Biology of reproduction - 1 Jul 2003

Meeks Joshua J, Russell Theron A, Jeffs Baxter, Huhtaniemi Ilpo, Weiss Jeffrey, Jameson J Larry

Abstract excerpt

Dax1 is an orphan nuclear receptor expressed in both Leydig and Sertoli cells of the testis. Mutation of DAX1 in humans causes adrenal failure and hypogonadotropic hypogonadism. Targeted mutagenesis of Dax1 in mice reveals a primary gonadal defect characterized by overexpression of aromatase and cellular obstruction of the seminiferous tubules and efferent ductules, leading to germ cell death and infertility....

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Identifiers

PMID: 12606353
DOI: 10.1095/biolreprod.102.011429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse.PMID 12606353Read ↗

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A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism.Semantic proximity Read ↗

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