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Article

Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity.

Antiviral therapy - 1 Jan 2010

Martin Mélanie, Azzi Arezki, Lin Sheng-Xiang, Boivin Guy

Abstract excerpt

BACKGROUND: Human cytomegalovirus (HCMV) infections cause significant morbidity in immunocompromised hosts. The aim of this study was to characterize the role of two HCMV DNA polymerase mutations (K805Q and T821I) found in a ganciclovir- and foscarnet-resistant clinical isolate from an AIDS patient. METHODS: The effects of single and dual DNA polymerase mutations on virus susceptibility and replicative capacity,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20587851
DOI: 10.3851/IMP1565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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