Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Empirical Validation of the Nearly Neutral Theory at Divergence and Population-Genomic Scales Using 144 Placental Mammal Genomes.

Genome biology and evolution - 1 Apr 2026

Bastian Mélodie, Enard David, Lartillot Nicolas

Abstract excerpt

By limiting the efficacy of selection, random drift is expected to play a major role in genome evolution. Formalizing this idea, the nearly-neutral theory predicts that the ratio of non-synonymous over synonymous polymorphism (πN/πS) within populations, and divergence (dN/dS) between species, should both correlate negatively with Ne. This has previously been tested in mammals and other groups. However, most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Genetic Drift
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Mammals

Share to Models, Genetic

Share to Polymorphism, Genetic

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 41936401
DOI: 10.1093/gbe/evag030
PMCID: PMC13050581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Empirical Validation of the Nearly Neutral Theory at Divergence and Population-Genomic Scales Using 144 Placental Mammal Genomes.PMID 41936401Read ↗

Reconstructing the History of Variation in Effective Population Size along Phylogenies.Semantic proximity Read ↗

The neutral theory of molecular evolution in the genomic era.Semantic proximity Read ↗

The contribution of historical processes to contemporary extinction risk in placental mammals.Semantic proximity Read ↗

A Comparative Analysis of Long-Term Effective Population Sizes Across Eukaryotes.Semantic proximity Read ↗

Comparative genomics and the study of evolution by natural selection.Semantic proximity Read ↗

The landscape of gene loss and missense variation across the mammalian tree informs on gene essentialitySemantic proximity Read ↗

The inflated significance of neutral genetic diversity in conservation genetics.Semantic proximity Read ↗

Deleterious mutations in animal mitochondrial DNA.Semantic proximity Read ↗

Recurrent loss of sex is associated with accumulation of deleterious mutations in Oenothera.Semantic proximity Read ↗

Neutral theory predicts the relative abundance and diversity of genetic elements in a broad array of eukaryotic genomes.Semantic proximity Read ↗

The relation between the neutrality index for mitochondrial genes and the distribution of mutational effects on fitness.Semantic proximity Read ↗

Quasi-neutral molecular evolution — When positive and negative selection cancel outSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.