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Article

The McDonald-Kreitman test and slightly deleterious mutations.

Molecular biology and evolution - 1 Jun 2008

Charlesworth Jane, Eyre-Walker Adam

Abstract excerpt

It is possible to estimate the proportion of substitutions that are due to adaptive evolution using the numbers of silent and nonsilent polymorphisms and substitutions in a McDonald and Kreitman-type analysis. Unfortunately, this estimate of adaptive evolution is biased downward by the segregation of slightly deleterious mutations. It has been suggested that 1 way to cope with the effects of these slightly...

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PMID: 18195052
DOI: 10.1093/molbev/msn005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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