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Article

Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.

International journal of molecular sciences - 7 Feb 2021

Rojas Pilar, Ramírez Ana I, Cadena Manuel, Fernández-Albarral José A, Salobrar-García Elena, López-Cuenca Inés, Santos-García Irene, de Lago Eva, Urcelay-Segura José L, Ramírez José M, de Hoz Rosa, Salazar Juan J

Abstract excerpt

The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS models. In this study, we quantified the signs of microglial activation and the number of retinal ganglion cells (RGCs) in an SOD1G93A transgenic mouse model at 120 days...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33562231
DOI: 10.3390/ijms22041663
PMCID: PMC7915199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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