Article
Functional Implications of Human-Specific Changes in Great Ape microRNAs.
PloS one - 1 Jan 2016
Gallego Alicia, Melé Marta, Balcells Ingrid, García-Ramallo Eva, Torruella-Loran Ignasi, Fernández-Bellon Hugo, Abelló Teresa, Kondova Ivanela, Bontrop Ronald, Hvilsom Christina, Navarro Arcadi, Marquès-Bonet Tomàs, Espinosa-Parrilla Yolanda
Abstract excerpt
microRNAs are crucial post-transcriptional regulators of gene expression involved in a wide range of biological processes. Although microRNAs are highly conserved among species, the functional implications of existing lineage-specific changes and their role in determining differences between humans and other great apes have not been specifically addressed. We analyzed the recent evolutionary history of 1,595...
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