Article
Opposites Attract: Escherichia coli Heptosyltransferase I Conformational Changes Induced by Interactions between the Substrate and Positively Charged Residues.
Biochemistry - 1 Sept 2020
Cote Joy M, Hecht Cody J S, Patel Kaelan R, Ramirez-Mondragon Carlos A, Sham Yuk Y, Taylor Erika A
Abstract excerpt
Gram-negative bacterial viability is greatly reduced by the disruption of heptose sugar addition during the biosynthesis of lipopolysaccharide (LPS), an important bacterial outer membrane component. Heptosyltransferase I (HepI), a member of the GT-B structural subclass of glycosyltransferases, is therefore an essential enzyme for the biosynthesis of the LPS. The disruption of HepI also increases the...
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