Effects of a HP0859 (rfaD) knockout mutation on lipopolysaccharide structure of Helicobacter pylori 26695 and the bacterial adhesion on AGS cells.

doi:10.1016/j.bbrc.2011.01.060

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Article

Effects of a HP0859 (rfaD) knockout mutation on lipopolysaccharide structure of Helicobacter pylori 26695 and the bacterial adhesion on AGS cells.

Biochemical and biophysical research communications - 18 Feb 2011

Chang Po-Chun, Wang Chun-Jen, You Chung-Kai, Kao Mou-Chieh

Abstract excerpt

Lipopolysaccharide (LPS) is considered as an important virulence factor of Helicobacter pylori, and contributes to infection persistence and disease severity. ADP-L-glycero-D-manno-heptose-6-epimerase is an enzyme essential for LPS synthesis and understanding of its biochemistry is critical for drug development. We cloned one putative ortholog of Escherichia colirfaD, HP0859, from H. pylori 26695. Determination...

Topics

Bacterial Adhesion
Carbohydrate Epimerases
Cell Line, Tumor
Cloning, Molecular
Gene Knockout Techniques
Helicobacter pylori
Humans
Lipopolysaccharides
Mutation

Source

Open in PubMed

Identifiers

PMID: 21256827
DOI: 10.1016/j.bbrc.2011.01.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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