Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Examining the role of intersubunit contacts in catalysis by 3-deoxy-d-manno-octulosonate 8-phosphate synthase.

Biochemistry - 9 Jul 2013

Allison Timothy M, Cochrane Fiona C, Jameson Geoffrey B, Parker Emily J

Abstract excerpt

3-Deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) catalyzes the reaction between phosphoenolpyruvate and arabinose 5-phosphate (A5P) in the first committed step in the pathway to 3-deoxy-d-manno-octulosonate, a component in the cell wall of Gram-negative bacteria. KDO8PS is evolutionarily and structurally related to the first enzyme of the shikimate pathway, 3-deoxy-d-arabino-heptulosonate 7-phosphate...

Topics

Join the communities discussing this publication.

Aldehyde-Lyases
Biocatalysis
Crystallography, X-Ray
Gram-Negative Bacteria
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Protein Conformation

Source

Identifiers

PMID: 23746359
DOI: 10.1021/bi400521f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Examining the role of intersubunit contacts in catalysis by 3-deoxy-d-manno-octulosonate 8-phosphate synthase.PMID 23746359Read ↗

Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase.Semantic proximity Read ↗

The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.Semantic proximity Read ↗

Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.Semantic proximity Read ↗

Designing a metal-binding site in the scaffold of Escherichia coli KDO8PS.Semantic proximity Read ↗

Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.Semantic proximity Read ↗

Structural basis for substrate specificity in phosphate binding (beta/alpha)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12.Semantic proximity Read ↗

Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis.Semantic proximity Read ↗

The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism.Semantic proximity Read ↗

Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.Semantic proximity Read ↗

Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates.Semantic proximity Read ↗

Creation of a shikimate pathway variant.Semantic proximity Read ↗

Aromatic residues in mobile regions distal to the active site support the closed conformation of <i>E. coli</i> DXPSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.