Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.

doi:10.1021/jm301483h

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Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.

Journal of medicinal chemistry - 28 Feb 2013

Lee Ting-Wai, Verhey Theodore B, Antiperovitch Pavel A, Atamanyuk Dmytro, Desroy Nicolas, Oliveira Chrystelle, Denis Alexis, Gerusz Vincent, Drocourt Elodie, Loutet Slade A, Hamad Mohamad A, Stanetty Christian, Andres Sara N, Sugiman-Marangos Seiji, Kosma Paul, Valvano Miguel A, Moreau Francois, Junop Murray S

Abstract excerpt

As an essential constituent of the outer membrane of Gram-negative bacteria, lipopolysaccharide contributes significantly to virulence and antibiotic resistance. The lipopolysaccharide biosynthetic pathway therefore serves as a promising therapeutic target for antivirulence drugs and antibiotic adjuvants. Here we report the structural-functional studies of D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA), an...

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PMID: 23256532
DOI: 10.1021/jm301483h
PMCID: PMC3585733

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