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Article

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.

Cancer research - 1 Sept 2009

Pratap Jitesh, Imbalzano Karen M, Underwood Jean M, Cohet Nathalie, Gokul Karthiga, Akech Jacqueline, van Wijnen Andre J, Stein Janet L, Imbalzano Anthony N, Nickerson Jeffrey A, Lian Jane B, Stein Gary S

Abstract excerpt

The transcription factor Runx2 is highly expressed in breast cancer cells compared with mammary epithelial cells and contributes to metastasis. Here we directly show that Runx2 expression promotes a tumor cell phenotype of mammary acini in three-dimensional culture. Human mammary epithelial cells (MCF-10A) form polarized, growth-arrested, acini-like structures with glandular architecture. The ectopic expression...

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Source

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Identifiers

PMID: 19690135
DOI: 10.1158/0008-5472.CAN-09-1471
PMCID: PMC2742766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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