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Understanding cancer cell plasticity: EMT, respecialisation, and therapeutic opportunities

26 Aug 2025

Abstract excerpt

Cancer therapeutic resistance is mediated, in part, by phenotypic heterogeneity and the plasticity of tumor cells, the latter being enabled by epithelial–mesenchymal transition (EMT). However, EMT in human cancer therapeutic response remains poorly understood. We developed patient-derived organoids (PDOs) from human triple-negative breast cancer (TNBC) and investigated their response to chemotherapy. We found...

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PMID: 40859054
DOI: 10.1038/s44321-025-00288-2

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