Article
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
PloS one - 1 Jan 2012
D'Amato Nicholas C, Ostrander Julie H, Bowie Michelle L, Sistrunk Christopher, Borowsky Alexander, Cardiff Robert D, Bell Katie, Young Lawrence J T, Simin Karl, Bachelder Robin E, Delrow Jeff, Dawson Alyssa, Yee Lisa D, Mrózek Krzysztof, Clay Timothy M, Osada Takuya, Seewaldt Victoria L
Abstract excerpt
Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry a poor prognosis. Basal-like breast cancers are enriched for markers of breast cancer stem cells as well as markers of epithelial-mesenchymal transition (EMT). While EMT is generally thought to be important in the process of metastasis, in vivo evidence of EMT in human disease remains rare. Here we...
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