B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis

Abstract excerpt

Reciprocal partnership between B and CD4 T cells is crucial for their optimum responses in adaptive immunity. Immune responses augmented by their partnership promote chronic inflammation. Here we report that interdependent collaboration between B and CD4 T cells augments their atherogenic function to promote lipid-induced atherosclerosis. Genetic deletion of the gene encoding immunoglobulin mu (μ) heavy chain...

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