Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation.

doi:10.1038/s41375-019-0685-4

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Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation.

Leukemia - 1 Jul 2020

Kim Rathana, Boissel Nicolas, Touzart Aurore, Leguay Thibaut, Thonier Florian, Thomas Xavier, Raffoux Emmanuel, Huguet Françoise, Villarese Patrick, Fourrage Cécile, Passini Loïc, Hunault Mathilde, Lepretre Stéphane, Chevallier Patrice, Braun Thorsten, Lhéritier Véronique, Chantepie Sylvain, Maury Sébastien, Escoffre Martine, Tavernier Emmanuelle, Chalandon Yves, Graux Carlos, Macintyre Elizabeth, Ifrah Norbert, Asnafi Vahid, Dombret Hervé, Lhermitte Ludovic

Abstract excerpt

The prognostic value of IL7-receptor pathway (IL7Rp) mutations in T-cell acute lymphoblastic leukemia (T-ALL) remains unclear. We performed a comprehensive study of 200 adult patients with T-ALL included in the GRAALL2003/2005 protocols to address the clinical significance of IL7Rp mutations. Next-generation sequencing of the IL7Rp (IL7R/JAK1/JAK3/STAT5B) revealed that IL7Rp mutations were frequent in adult T-ALL...

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PMID: 31992840
DOI: 10.1038/s41375-019-0685-4

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