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Article

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.

Cell host & microbe - 12 Feb 2020

Krishnan Aarti, Kloehn Joachim, Lunghi Matteo, Chiappino-Pepe Anush, Waldman Benjamin S, Nicolas Damien, Varesio Emmanuel, Hehl Adrian, Lourido Sebastian, Hatzimanikatis Vassily, Soldati-Favre Dominique

Abstract excerpt

To survive and proliferate in diverse host environments with varying nutrient availability, the obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have generated and curated a genome-scale metabolic model (iTgo) for the fast-replicating tachyzoite stage, harmonized with experimentally observed phenotypes. To validate the importance of four metabolic pathways predicted by the model, we...

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PMID: 31991093
DOI: 10.1016/j.chom.2020.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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