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Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi

6 Oct 2020

Abstract excerpt

Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan called Trypanosoma cruzi. This parasite presents a complex multi-stage life cycle. Anti-Chagas drugs currently available are limited to benznidazole and nifurtimox, both with severe side effects. Thus, there is a need for alternative and more efficient drugs. Genome-scale metabolic models...

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PMID: 33021977
DOI: 10.1371/journal.pntd.0008728

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