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The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

12 Jul 2023

Abstract excerpt

The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here, we used TurboID and genome engineering to identify apicoplast transporters in Toxoplasma gondii . Among the many novel transporters, we show that one pair of apicomplexan...

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PMID: 38502570
DOI: 10.7554/elife.88866

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