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Article

Metabolic adaptability and nutrient scavenging in Toxoplasma gondii: insights from ingestion pathway-deficient mutants.

mSphere - 29 Apr 2025

Rimple Patrick A, Olafsson Einar B, Markus Benedikt M, Wang Fengrong, Augusto Leonardo, Lourido Sebastian, Carruthers Vern B

Abstract excerpt

The obligate intracellular parasite Toxoplasma gondii replicates within a specialized compartment called the parasitophorous vacuole (PV). Recent work showed that despite living within a PV, Toxoplasma endocytoses proteins from the cytosol of infected host cells via a so-called ingestion pathway. The ingestion pathway is initiated by dense granule protein GRA14, which binds host endosomal sorting complex required...

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Identifiers

PMID: 40172222
DOI: 10.1128/msphere.01011-24
PMCID: PMC12039266

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