Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens.

Abstract excerpt

BACKGROUND: Chemical carcinogens such as benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may contribute to the etiology of human diet-associated cancer. Individually, these compounds are genotoxic, but the consequences of exposure to mixtures of these chemicals hav...

Topics

• Benzo(a)pyrene
• Carcinogens
• Cell Line
• Cell Line, Tumor
• Cytochrome P-450 CYP1A1
• DNA Damage
• Humans
• Imidazoles
• Mutation
• RNA, Messenger