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Article

Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss.

Experimental & molecular medicine - 1 Jan 2020

Tajima Shori, Danzaki Keiko, Ikeda Katsuhisa, Kamiya Kazusaku

Abstract excerpt

Age-related hearing loss (ARHL) is the progressive, bilateral loss of high-frequency hearing in elderly people. Mutations in GJB2, encoding the cochlear gap junction protein connexin26 (Cx26), are the most frequent cause of hereditary deafness; however, a common molecular pathology between ARHL and GJB2-related hearing loss has not been reported. Here, we investigated the quantitative change in expression and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31988333
DOI: 10.1038/s12276-020-0377-1
PMCID: PMC7000393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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