Article
Functional studies reveal new mechanisms for deafness caused by connexin mutations.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Feb 2009
Chang Qing, Tang Wenxue, Ahmad Shoeb, Stong Benjamin, Leu Grace, Lin Xi
Abstract excerpt
OBJECTIVE: Connexin26 (Cx26) and Cx30 are the major protein subunits forming gap junction (GJ) intercellular channels in the cochlea. Mutations in these 2 Cxs are the major cause of nonsyndromic early childhood deafness in humans. The underlying mechanism for cochlear abnormality is unclear. Here, we used targeted Cx30 gene deletion (Cx30-/-) mice to investigate molecular mechanisms responsible for Cx...
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