Article
Mice with conditional deletion of Cx26 exhibit no vestibular phenotype despite secondary loss of Cx30 in the vestibular end organs.
Hearing research - 1 Oct 2015
Lee Min Young, Takada Tomoko, Takada Yohei, Kappy Michelle D, Beyer Lisa A, Swiderski Donald L, Godin Ashley L, Brewer Shannon, King W Michael, Raphael Yehoash
Abstract excerpt
Connexins are components of gap junctions which facilitate transfer of small molecules between cells. One member of the connexin family, Connexin 26 (Cx26), is prevalent in gap junctions in sensory epithelia of the inner ear. Mutations of GJB2, the gene encoding Cx26, cause significant hearing loss in humans. The vestibular system, however, does not usually show significant functional deficits in humans with this...
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