Article
High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2022
Stutte Susanne, Ishikawa-Ankerhold Hellen, Lynch Lydia, Eickhoff Sarah, Nasiscionyte Simona, Guo Chenglong, van den Heuvel Dominic, Setzensack Daniel, Colonna Marco, Maier-Begandt Daniela, Weckbach Ludwig, Brocker Thomas, Schulz Christian, Walzog Barbara, von Andrian Ulrich
Abstract excerpt
Plasmacytoid dendritic cells (pDCs) display an increased abundance in visceral adipose tissue (VAT) of humans with obesity. In the current study, we set out to decipher the molecular mechanisms of their recruitment to VAT and the functional relevance of this process. We observed increased pDC numbers in murine blood, liver, spleen, and VAT after feeding a high-fat diet (HFD) for 3 wk when compared with a standard...
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