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Article

Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells.

Scientific reports - 19 Nov 2015

Onodera Toshiharu, Fukuhara Atsunori, Jang Myoung Ho, Shin Jihoon, Aoi Keita, Kikuta Junichi, Otsuki Michio, Ishii Masaru, Shimomura Iichiro

Abstract excerpt

Numerous regulatory T cells (Tregs) are present in adipose tissues compared with other lymphoid or non-lymphoid tissues. Adipose Tregs regulate inflammatory state and insulin sensitivity. However, the mechanism that maintains Tregs in adipose tissue remains unclear. Here, we revealed the contribution of adipose tissue macrophages (ATMs) to the induction and proliferation of adipose Tregs. ATMs isolated from mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diet, High-Fat

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Source

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Identifiers

PMID: 26582486
DOI: 10.1038/srep16801
PMCID: PMC4652162

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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