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Article

Generation of a ChATCre mouse line without the early onset hearing loss typical of the C57BL/6J strain.

Hearing research - 15 Mar 2020

Beebe Nichole L, Sowick Colleen S, Kristaponyte Inga, Galazyuk Alexander V, Vetter Douglas E, Cox Brandon C, Schofield Brett R

Abstract excerpt

The development of knockin mice with Cre recombinase expressed under the control of the promoter for choline acetyltransferase (ChAT) has allowed experimental manipulation of cholinergic circuits. However, currently available ChATCre mouse lines are on the C57BL/6J strain background, which shows early onset age-related hearing loss attributed to the Cdh23753A mutation (a.k.a., the ahl mutation). To develop...

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Identifiers

PMID: 31982642
DOI: 10.1016/j.heares.2020.107896
PMCID: PMC7369543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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