Article
Fine mapping of Ahl3 affecting both age-related and noise-induced hearing loss.
Biochemical and biophysical research communications - 30 Mar 2007
Morita Yuka, Hirokawa Sachiko, Kikkawa Yoshiaki, Nomura Tomoyuki, Yonekawa Hiromichi, Shiroishi Toshihiko, Takahashi Sugata, Kominami Ryo
Abstract excerpt
A region in the vicinity of D17Mit119 on mouse chromosome 17 harbors a susceptibility gene, designated as Ahl3, to age-related hearing loss (AHL). We produced congenic lines of C57BL/6 background that substituted regions around D17Mit119 with MSM-derived ones, and examined auditory brainstem response (ABR) thresholds for their hearing capacity at 6 and 12months of age. Three congenic lines carrying the...
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