Article
African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Nature communications - 24 Jan 2020
Singh Kumar Sachin, Leu Julia I-Ju, Barnoud Thibaut, Vonteddu Prashanthi, Gnanapradeepan Keerthana, Lin Cindy, Liu Qin, Barton James C, Kossenkov Andrew V, George Donna L, Murphy Maureen E, Dotiwala Farokh
Abstract excerpt
A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters macrophage cytokine profiles, leads to higher arginase level and activity, and decreased nitric oxide synthase...
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