Article
Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.
Journal of innate immunity - 1 Jan 2016
Armitage Andrew E, Lim Pei Jin, Frost Joe N, Pasricha Sant-Rayn, Soilleux Elizabeth J, Evans Emma, Morovat Alireza, Santos Ana, Diaz Rebeca, Biggs Daniel, Davies Benjamin, Gileadi Uzi, Robbins Peter A, Lakhal-Littleton Samira, Drakesmith Hal
Abstract excerpt
Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapidly accumulate iron and are susceptible to infection by blood-dwelling siderophilic bacteria such...
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