Article
Iron overload causes macrophages to produce a pro-inflammatory phenotype in the synovium of hemophiliac arthritis via the acetyl-p53 pathway.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jan 2024
Pang Nanyu, Ding Mingyang, Yang Hu, Zhong Qigang, Zheng Liujie, Luo Dasheng, Yao Yunfeng
Abstract excerpt
AIM: Haemophiliac arthritis (HA) is caused by spontaneous intra-articular hemorrhage and repeated intra-articular hematomas, leading to iron overload, which, in turn, induces M1 macrophage polarisation and inflammatory cytokine secretion, resulting in synovitis. Here, we explored the mechanism by which iron overload in HA induces the polarisation of M1 macrophages, providing a new approach for the treatment of HA...
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