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Article

Ancestry-agnostic estimation of DNA sample contamination from sequence reads.

Genome research - 1 Feb 2020

Zhang Fan, Flickinger Matthew, Taliun Sarah A Gagliano, Abecasis Gonçalo R, Scott Laura J, McCaroll Steven A, Pato Carlos N, Boehnke Michael, Kang Hyun Min

Abstract excerpt

Detecting and estimating DNA sample contamination are important steps to ensure high-quality genotype calls and reliable downstream analysis. Existing methods rely on population allele frequency information for accurate estimation of contamination rates. Correctly specifying population allele frequencies for each individual in early stage of sequence analysis is impractical or even impossible for large-scale...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31980570
DOI: 10.1101/gr.246934.118
PMCID: PMC7050530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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