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Benchmarking for genotyping and imputation using degraded DNA for forensic applications across diverse populations.

Forensic science international. Genetics - 1 Feb 2025

Zavala Elena I, Rohlfs Rori V, Moorjani Priya

Abstract excerpt

Advancements in sequencing and laboratory technologies have enabled forensic genetic analysis on increasingly low quality and degraded DNA samples. However, existing computational methods applied to genotyping and imputation for generating DNA profiles from degraded DNA have not been tested for forensic applications. Here we simulated sequencing data of varying qualities-coverage, fragment lengths, and...

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Identifiers

PMID: 39586186
DOI: 10.1016/j.fsigen.2024.103177
PMCID: PMC12056732

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