Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Does Sclerostin Depletion Stimulate Fracture Healing in a Mouse Model?

Clinical orthopaedics and related research - 1 May 2016

Alzahrani Mohammad M, Rauch Frank, Hamdy Reggie C

Abstract excerpt

BACKGROUND: Sclerostin is a secreted glycoprotein that inhibits the intracellular Wnt signaling pathway, which, when inactivated, stimulates bone formation. This has been seen in fracture studies, which have shown larger and stronger calluses with accelerated fracture healing in sclerostin knockout and sclerostin antibody injection models. However, the effects of these two mechanisms have not been compared in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Antibodies
Share to Biomechanical Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Remodeling

Share to Glycoproteins

Share to Intercellular Signaling Peptides and Proteins

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 26608966
DOI: 10.1007/s11999-015-4640-z
PMCID: PMC4814400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does Sclerostin Depletion Stimulate Fracture Healing in a Mouse Model?PMID 26608966Read ↗

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.Semantic proximity Read ↗

SclerostinSemantic proximity Read ↗

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.Semantic proximity Read ↗

Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis ImperfectaSemantic proximity Read ↗

Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.Semantic proximity Read ↗

Sclerostin-Antibody Treatment Decreases Fracture Rates in Axial Skeleton and Improves the Skeletal Phenotype in Growing oim/oim Mice.Semantic proximity Read ↗

The Role of Sclerostin in Bone DiseasesSemantic proximity Read ↗

Sclerostin Antibody Treatment Improves the Bone Phenotype of Crtap–/– Mice, a Model of Recessive Osteogenesis ImperfectaSemantic proximity Read ↗

Sclerostin: Current Knowledge and Future PerspectivesSemantic proximity Read ↗

Osteocyte control of bone formation via sclerostin, a novel BMP antagonistSemantic proximity Read ↗

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.Semantic proximity Read ↗

Sclerostin antibody enhances implant osseointegration in bone with Col1a1 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.