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Article

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.

Bone - 1 Mar 2016

Taylor Scott, Ominsky Michael S, Hu Rong, Pacheco Efrain, He Yudong D, Brown Danielle L, Aguirre J Ignacio, Wronski Thomas J, Buntich Sabina, Afshari Cynthia A, Pyrah Ian, Nioi Paul, Boyce Rogely Waite

Abstract excerpt

Inhibition of sclerostin with sclerostin antibody (Scl-Ab) has been shown to stimulate bone formation, decrease bone resorption, and increase bone mass in both animals and humans. To obtain insight into the temporal cellular and transcriptional changes in the osteoblast (OB) lineage associated with long-term Scl-Ab treatment, stereological and transcriptional analyses of the OB lineage were performed on lumbar...

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PMID: 26721737
DOI: 10.1016/j.bone.2015.12.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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