Article
In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air-Liquid Interface Cultures.
SLAS technology - 1 Jun 2020
Marescotti Diego, Bovard David, Morelli Moran, Sandoz Antonin, Luettich Karsta, Frentzel Stefan, Peitsch Manuel, Hoeng Julia
Abstract excerpt
High-content imaging (HCI) is a powerful method for quantifying biological effects in vitro. Historically, HCI has been applied to adherent cells growing in monolayers. With the advent of confocal versions of HCI devices, researchers now have the option of performing analyses on 3D cell cultures. However, some obstacles remain in integrating the third dimension, such as limited light penetration and less...
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