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Article

Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses.

Science signaling - 29 Oct 2013

Montefusco David J, Chen Lujia, Matmati Nabil, Lu Songjian, Newcomb Benjamin, Cooper Gregory F, Hannun Yusuf A, Lu Xinghua

Abstract excerpt

Ceramide, the central molecule of sphingolipid metabolism, is an important bioactive molecule that participates in various cellular regulatory events and that has been implicated in disease. Deciphering ceramide signaling is challenging because multiple ceramide species exist, and many of them may have distinct functions. We applied systems biology and molecular approaches to perturb ceramide metabolism in the...

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Identifiers

PMID: 24170935
DOI: 10.1126/scisignal.2004515
PMCID: PMC3974757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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