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Article

mPGES-1 as a novel target for arthritis

1 Sept 2004

Abstract excerpt

PURPOSE OF REVIEW: Prostaglandin E2 (PGE2) is by far the major prostanoid synthesized in the joint and plays an important role in inflammation and pathogenesis of arthritis. Moreover, increased levels of PGE2 have been detected in serum and synovial fluids from arthritic patients. Little was known about the enzyme(s) involved in the isomerization of PGH2 into PGE2 synthesis until recent identification of PGE...

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PMID: 15314505
DOI: 10.1097/01.bor.0000129664.81052.8e

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