Article
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2013
Raghuwanshi Sandeep K, Smith Nikia, Rivers Elizabeth J, Thomas Ariel J, Sutton Natalie, Hu Yuhui, Mukhopadhyay Somnath, Chen Xiaoxin L, Leung TinChung, Richardson Ricardo M
Abstract excerpt
G protein-coupled receptor kinases (GRKs) phosphorylate the activated form of G protein-coupled receptors leading to receptor desensitization and downregulation. We have recently shown that the chemokine receptor, CXCR2, couples to GRK6 to regulate cellular responses including chemotaxis, angiogenesis, and wound healing. In this study, we investigate the role of GRK6 in tumorigenesis using murine models of human...
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