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Article

Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance.

The Journal of experimental medicine - 1 Mar 2021

He Feng, Huang Yanrui, Song Zhi, Zhou Huanjiao Jenny, Zhang Haifeng, Perry Rachel J, Shulman Gerald I, Min Wang

Abstract excerpt

White adipose tissues (WAT) play crucial roles in maintaining whole-body energy homeostasis, and their dysfunction can contribute to hepatic insulin resistance and type 2 diabetes mellitus (T2DM). However, the mechanisms underlying these alterations remain unknown. By analyzing the transcriptome landscape in human adipocytes based on available RNA-seq datasets from lean, obese, and T2DM patients, we reveal...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequestosome-1 Protein

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Identifiers

PMID: 33315085
DOI: 10.1084/jem.20201416
PMCID: PMC7927432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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