Article
Deficiency of the tumor promoter gene wip1 induces insulin resistance.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2015
Armata Heather L, Chamberland Sally, Watts Lauren, Ko Hwi Jin, Lee Yongjin, Jung Dae Young, Kim Jason K, Sluss Hayla K
Abstract excerpt
Diabetes is a growing health care issue, and prediabetes has been established as a risk factor for type 2 diabetes. Prediabetes is characterized by deregulated glucose control, and elucidating pathways which govern this process is critical. We have identified the wild-type (WT) p53-inducible phosphatase (WIP1) phosphatase as a regulator of glucose homeostasis. Initial characterization of insulin signaling in WIP1...
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