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FBXW2 Inhibits Prostate Cancer Progression and Metastasis Via Promoting EGFR Ubiquitylation and Degradation

2021-11-11

Abstract excerpt

<h4>Background: </h4> The process of ubiquitylation, carried out by a three-step enzymatic cascade, maintains the balance of intracellular proteins and the stability of their functions. FBXW2 is a novel F-box protein, and acts as a tumor suppressor gene in lung cancer by directly degrading substrates or regulating the other E3 ligases. However, whether or how FBXW2 regulates prostate cancer (PCa) tumorigenesis and...

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Literature Corpus work
aca37668-9e97-5804-958e-900e104b58b8
DOI
10.21203/rs.3.rs-1006015/v1
Open publication

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FBXW2 Inhibits Prostate Cancer Progression and Metastasis Via Promoting EGFR Ubiquitylation and DegradationDOI 10.21203/rs.3.rs-1006015/v1
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