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Genome-scale CRISPR screening for potential targets of ginsenoside compound K

20 Jan 2020

Abstract excerpt

Ginsenosides exhibit a large variety of biological activities in maintaining physical health; however, the molecule underpinnings underlining these biological activities remain to be defined. Here, we took a cellular condition that compound K (CK) induces autophagic cell death in HeLa cells, and setup a high-throughput genetic screening using CRISPR technology. We have identified a number of CK-resistant and...

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PMID: 31959745
DOI: 10.1038/s41419-020-2234-5

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